Diseases That Can Lead to Erectile Dysfunction The link between underlying chronic disease and erectile dysfunction is most striking with diabetes. Approximately half of the men with diabetes experience erectile dysfunction. Nevertheless, good blood sugar control can minimize this risk. In addition, the following four diseases can lead to erectile dysfunction by interfering with blood flow or nerve impulses throughout the body. Cardiovascular disease Atherosclerosis (hardening of the arteries) Kidney disease Multiple sclerosis
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