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May Increase Your Triglycerides and Lower Your HDL Cholesterol High amounts of added sugar can increase triglycerides and lower good cholesterol in the blood. According to a 2020 study in the Journal of the American Heart Association, adults who drink soda frequently have a 98% higher risk of having low HDL levels ("good" cholesterol) and a 53% higher chance of developing high triglycerides. May Cause Changes in Your Gut Microbiota While artificial sweeteners were originally used as a "healthier" alternative, some research has shown that might not be the case. "A study published last year found that artificial sweeteners, such as the ones found in diet sodas, may negatively affect the gut microbiome and glycemic control," says Davis, which was published in 2022 in Cell. May Increase Your Risk of Health Conditions As noted by the CDC, drinking soda frequently is associated with an increased risk of several medical problems, including obesity, diabetes, incr